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[232] [198] In addition to presynaptic actions that regulate DAT, TAAR1 activation exerts a somatodendritic inhibitory influence on midbrain dopamine neurons by reducing their firing rate via G protein-coupled inwardly-rectifying potassium channels, an effect that is expected to reduce action potential-dependent (vesicular) dopamine release into the synaptic cleft

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Senator Richard Blumenthal, speaking at a news conference at the state Capitol

Safety and immunogenicity of the -synuclein active immunotherapeutic PD01A in patients with Parkinsons disease: a randomised, single-blinded, phase 1 trial