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The mechanism seems to be independent of the catalytic activity, since these effects were not mimicked by systemic DPP-4 inhibition (73, 82), and it was suggested that soluble DPP-4 interacted with caveolin-1 on adipose tissue macrophages, the down-stream effects of which combined with actions of other pro-inflammatory molecules such as factor Xa, to lead to activation of the inflammatory signaling pathway (83) (Figure 3)

However, this method often hides the connection between cause and effect

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This post is primarily written for healthcare providers , but if any well-informed patients believe they qualify for treatment and were denied, feel free to share this information with your medical provider