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The concomitant use of alcohol or central nervous system (CNS) depressant drugs (e.g., barbiturates, benzodiazepines, and sleep medications) with phentermine or topiramate may potentiate CNS depression or other centrally mediated effects of these agents

phentermine: side effects Similar to any medication even over-the-counter options like aspirin Wegovy may cause side effects, which can range from mild and uncomfortable to more serious