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Clinical recommendations based upon the patient's renal function include [see Dosage and Administration (2.2), Clinical Pharmacology (12.3)]: Before initiating JANUMET XR, obtain an estimated glomerular filtration rate (eGFR)

In addition to increasing the likelihood of natural disasters (192), anthropogenic climate change has gradually led to environmental alterations, such as air pollution, loss of biodiversity, resource depletion, more frequent and heightened heatwaves, deforestation, and exacerbating water shortages, which may result in a wide range of health concerns, including instability and insecurity of resources, particularly food insecurity (180, 187, 188)

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