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Oral tablets do not require the use of needles are typically taken daily can result in side effects such as nausea, vomiting, constipation, and abdominal pain must be taken on an empty stomach first thing in the morning, without eating for 30 minutes afterward Injections require the use of needles are typically taken once per week may cause side effects such as injection site reactions but may also cause nausea, vomiting, constipation, and abdominal pain can be taken regardless of whether you consume food or liquid beforehand or afterward You can inject semaglutide into your upper arm, thigh, or stomach

In response to growing concern surrounding delayed gastric emptying and aspiration risk, anesthesia societies and regulatory agencies have issued updated guidance addressing perioperative management of patients taking semaglutide and tirzepatide medications

This happens largely because appetite returns to previous levels, and the metabolic improvements gained during treatment are no longer present

Combination therapies should be offered as a first line of treatment and not as a last resort for patients with severe and complex obesity