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The most informative difference between MES-1 and MES-2 clusters appears to be related to the expression of myogenic markers Myod1, Cdh15 and Peg3 in the cluster of MES-2 myofibroblast: the activation of Myod1 should suppress the connective tissue potential and seal the myogenic fate along with Cdh15, while the expression of Peg3 regulates skeletal muscle lineage commitment and is expressed in both muscle satellite cells and interstitial progenitor cells of non-muscle nature 28

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Symptoms may include: Penile curvature or bending during erection Palpable hardened plaque or nodules Penile pain (especially in early or active phases) Erectile dysfunction Loss of length or girth While some cases stabilize on their own, many men seek treatment when symptoms persist or worsen