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10.1016/j.cell.2013.12.010 Cell 195 YeeC.YangW.HekimiS

The 2 mg starting step is not expected to deliver a maintenance-level effect its only job is to introduce the molecule gently

however, these findings highlight one of the complexities of using antioxidant therapies, as increased GPx1 activity was correlated with enhanced ERK1/2 activation when analyzing memory, whereas increased GPx1 correlated with a decrease in ERK1/2 activation in the hypoxic preconditioning study, presumably due to the loss of hydrogen peroxide-mediated ERK1/2 activation