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A similar effect can happen with other treatments such as retinoids, like retinol, that may cause purging due to the way they impact how skin cells move from the lower layers to the surface (1, 2)

Thus I hypothesized that GLP-1 signaling may respond similarly to minimal exposure

And regardless of how they work, theyre all trying to help keep that airway open during sleep, but generally advise saving these oral appliances for more mild cases of sleep apnea, or if CPAP isnt tolerated, since these appliances have less evidence of benefit than CPAP

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