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Studying GLP-1, GIP, and glucagon triple RA for the treatment of MASLD/MASH follows the success of mono- and dual-agonists helping patients with type 2 diabetes and obesity achieve clinical targets by offering advantages of each constitutive component while minimising the risk of undesirable effects

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26,27 A Phase II trial in T2D showed a 1% reduction in HbA1c (Diabetes Control and Complications Trial units) and approximately 1.7% body weight reduction over 12 weeks, in comparison to placebo, but a further comparison to an open-label liraglutide active treatment control group was less impressive

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