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J Intern Med

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6 Delivery of flavonoids using novel strategies 6.1 Topical delivery strategies for flavonoids Innovative transdermal delivery systems have demonstrated measurable improvements in enhancing the topical bioavailability of poorly soluble agents

Further development of TGR-based therapeutic approaches is impeded by the lack of non-covalent small molecule inhibitors of TGR, a well-known and general problem for all the members of the high molecular weight, Sec-containing TrxR subfamily that are considered attractive and unexploited drug targets for several human diseases 21,22