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The observed reduction in AUD risk is particularly noteworthy given the global burden of AUD, which affects an estimated 280 million people and is associated with high morbidity and mortality [34]

To interrogate the mechanisms underlying NRF2-directed regulation of this core gene set, we compared mean promoter (1 kb restricted) ChIP-seq signal in A549 for NRF2, p300, as well as the histone marks H3K4me3 and H3K27ac, which are enriched at promoters and enhancers, respectively

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