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The use of human keratinocytes and human skin models for predicting skin irritation

Shows potential for stress reduction and mood support through HPA axis modulation

PRODUCT FOCUS: PEPTIDES AND PROTEINS PROCESS FOCUS: FORMULATION/STABILITY WHO SHOULD READ: ANALYTICAL AND FORMULATION DEVELOPMENT, PROCESS DEVELOPMENT, QA/QC AND REGULATORY AFFAIRS KEYWORDS: FORCED DEGRADATION, PROTEIN DEGRADATION, OXIDATION, DISULFIDE SCRAMBLING, DEAMIDATION, AGGREGATION, HYDROLYSIS LEVEL: INTERMEDIATE Advances in analytical chemistry have identified many degradation pathways that can occur in recombinant protein therapeutics over time

J Pharmacol Sci 95: 1926