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Methods: NNT was calculated for eight stroke clinical rials/meta-analyses purposively selected to include small, moderate and large treatment effects and diverse treatment types, including thrombolysis (NINDS tPA, IST3), thrombectomy (HERMES, AURORA, Large Core EVT), surgery for AIS (Hemicraniectomy), surgery for ICH (ENRICH), and blood pressure control (OPTIMAL BP)