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These shifts happen because GLP-1 signaling dampens the release of hunger hormones like ghrelin while boosting satiety signals from cholecystokinin and peptide YY

REFERENCES United Nations Office on Drugs and Crime

Moreover, given no heterogeneous treatment effects found by age, gender, or diabetes severity for GLP-1RAs versus insulin in our previous analyses [6] and limited study subjects with different patient characteristics in the present study, performing the cost-effectiveness analysis stratified by different patient demographic or clinical characteristics would be infeasible

Severe or persistent gastrointestinal symptoms: Prolonged vomiting, diarrhea, or inability to maintain adequate fluid intake, which can lead to dehydration and low blood pressure, especially if you're taking diuretics or blood pressure medications