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While the complete results of the study have not yet been published, an initial press release in 2024 indicated that tirzepatide reduced the relative risk for the composite endpoint (HF urgent visit or hospitalization, oral diuretic intensification, or cardiovascular death) by 38%

Ten of the 11 letters also cite public health concerns resulting from the promotional communications, stating they create a misleading impression about the safety and efficacy of the product

To further implement GLP-1RA-centric combination therapy, we need to consider some evidence gaps (Table 4)