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The most frequently reported digestive complaints include nausea (affecting approximately 15-44% of patients depending on dose and indication), vomiting, diarrhea, abdominal pain, and constipation

Nausea (43%), diarrhea (33%), and vomiting (21%) are the most common, consistent with other GLP-1 medications

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20 Combined infusions of GIP and GLP-1 have additive insulinotropic effects in the non-diabetic state, 21 and resistance to GIP-induced insulin secretion in T2D can be reduced by a short period (weeks) of intensive glucose-lowering treatment (Figure 3C)