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The goal of the evaluation is to confirm that the patients symptom profile actually matches the mechanism of the compound being prescribed, and to identify any contraindications before starting

These acylglycines are generated in the mitochondria by conjugating acyl-CoAs to glycine in a reaction mediated by GLYAT (61)

doi: 10.3389/fmolb.2025.1754469 Received 26 November 2025 Revised 19 December 2025 Accepted 25 December 2025 Published 09 January 2026 Volume 12 - 2025 Edited by Guillermo Moyna, Universidad de la Repblica, Uruguay Reviewed by Khaled Tighanimine, Harvard University, United States Updates Copyright 2026 Chacn, Grnwaldt, Marmisolle, Martnez and Quijano

We can't really quantify precisely, you know, how much of a problem this is because individual data are not available