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Nevertheless, in human cell lines, butyrate selectively stimulates PYY secretion through mechanisms largely driven by HDAC inhibition ( In addition to signaling in the gut, activation of SCFAs-binding receptors might be important also in the adipose tissue
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Secondary endpoints were defined as pharmacodynamics and pharmacokinetic parameters including maximum serum concentration, time to maximum concentration, half-life, plasma clearance, and volume of distribution, as well as exploratory parameters including bodyweight, glycemic control, and overall hormone profile
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