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The article introduces the concept of the "Cartilage-gut-microbiome axis," emphasizing the interaction between the gut microbiome and cartilage, which could provide new therapeutic targets for OA

However, recent work has shown that, in addition to using histones as substrates for deacetylation, HDACs can also inhibit the acetylation of non-histone proteins and modulate diverse neurobiological processes [59, 60]

The clinical value of the blend depends on the patients medical history, symptoms, lifestyle, treatment goals, dosage and ability to follow the prescribed regimen

The method effectively avoids artefactual auto-oxidation of GSH during sample processing