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Another small study in 2010 conducted at Sapienza Universitys Department of Clinical Medicine in Rome found that combining L-carnitine with caloric restriction helped reduce insulin resistance and increase sensitivity

Clinical trials show average weight loss ranging from approximately 1017% of total body weight over 1218 months when combined with lifestyle changes

It is, however, important to consider the side effects of these treatments, which include nausea and vomiting, gastrointestinal issues such as diarrhea and constipation, hypoglycemia, and redness or swelling at the injection site

Another oncogenic transcription factor, c-JUN, also regulates gene expression in GLS1(Lukey et al