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MCH1R is a typical GPCR that couples to the activation of both G q and G i type G-proteins

On the first day, all mice groups were fed a low-choline diet (choline bitartrate 0.08%), and fecal samples from each experimental group were collected and stored at 80 C for subsequent gut microbiota typing analysis

cruzi infection, which modulates systemic infection levels and inflammatory responses in cardiac tissue and reduces immune cell infiltration, cardiomyocyte hypertrophy, fibrosis and the parasite load in heart tissue ( 2 +/NFAT-dependent pathological COX-2/mPGES-1/PGE2 pathway in trypanosome-infected cardiomyocytes, potentially conferring cardioprotection in infected mice ( In conclusion, the role played by COX-2 in Chagas disease may be related to the attenuation of increased NO levels, negatively affecting the antiparasitic activity of macrophages