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Conversely, the deacetylation of histones by histone deacetylases (HDAC) restricts access of transcription factors to the DNA and suppresses transcription

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The intracellular concentration of GSH is maintained through three primary mechanisms: (1) De novo synthesis, where glutamate-cysteine ligase (GCL) and glutathione synthase sequentially synthesize GSH from cysteine, glutamate, and glycine