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The intracellular part of LRP5/6 contains multiple phosphorylation sites, the phosphorylation of which is a key step in the initiation of signal transduction via Wnt/-catenin signalling

The peptide complex restores extracellular matrix homeostasis by increasing the synthesis and turnover of collagen, elastin, and glycosaminoglycans, as well as by modulating the balance between metalloproteinases (MMPs) and their inhibitors (TIMPs), thus supporting both matrix remodeling and scar resolution 2,3

There is strong evidence that high-platelet PRP therapy is effective for reducing pain and improving mobility in knee OA patients