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Ozbey-Yucel U, Ucar A, Aydogan Z, Tokgoz-Yilmaz S, Beton S

Recommended monitoring strategies include: Monitoring frequency individualised by severity and local protocols, with consideration of closer follow-up in the first year if pre-existing retinopathy Coordination between diabetes care teams and ophthalmology services Regular HbA1c monitoring to track the rate of glycaemic improvement Patient education about symptoms requiring urgent assessment Dose titration strategy may influence retinopathy risk

Low oxygen environment together with high concentrations of vitamin C in the aqueous and vitreous humors [10,44] and high levels of glutathione (GSH) [45] and vitamin C [10] in the lens, ensures protection of the lens against oxidative stress

This is consistent with the theory of local area network inhibition, which posits that excessive or unstable excitatory activity can induce homeostatic over-inhibition, thereby contributing to clinical symptomswhose precise manifestations depend on the neural networks involved