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Niacin is crucial for the biochemistry of the nervous system, playing a significant role in energy metabolism, antioxidant activities, and the synthesis of essential molecules for neuronal function, such as acting in dopamine synthesis ()

Figure 3 Skin Rash Skin manifestations during ICI therapy show the highest incidence of irAEs and appear higher in patients with melanoma than in patients with other malignancies (124)

Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection

Role of gut microbiota-generated short-chain fatty acids in metabolic and cardiovascular health