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Reference: Hsieh et al., 2017 (VEGFR2AkteNOS signalling involvement) VEGFR2 activation triggers: VEGF binding VEGFR2 autophosphorylation (turns on VEGFR2) which leads to PI3K activation which leads to Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis more nitric oxide

The discovery of GLP-1 and its role in regulating blood glucose was a major scientific breakthrough in diabetes research, yet turning this peptide hormone into an effective medication was no easy task

doi: 10.1007/s10620-012-2362-6