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It is also noteworthy that central GLP-1R signaling appears to be impaired in chronic stress conditions or under the influence of a high concentration of glucocorticoids, often observed in patients with depression

Serious but rare risks include hypoglycemia (low blood sugar), acute pancreatitis (severe, persistent abdominal pain often with vomiting), acute gallbladder disease (sudden right-upper abdominal pain that may radiate to the shoulder), non-arteritic anterior ischemic optic neuropathy (sudden, potentially permanent vision loss), mood changes, and severe allergic reactions with breathing difficulty or swelling of the lips, tongue, or throat

Academy of Nutrition and Dietetics: eatright.org

Quick, empowering story: Bethany, 47, was completely new to strength training and nervous to start