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However, a key challenge remains: it is unclear whether the findings from models involving unilateral deafness are consistent with those from models using subjects with normal binaural hearing
Treatment decisions are made collaboratively, with patients receiving detailed information about the experimental nature of many peptide therapies and the importance of ongoing research
While this positions cagrilintide as slightly less potent in vitro than salmon calcitonin (sCT, pEC ~1112), its superior stability, reduced aggregation risk, and long acting pharmacokinetic profile make it far more practical for sustained receptor engagement in both animal models and clinical investigation
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