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In patients with obesity, with or without diabetes, significant weight loss (and improvement in weight-related complications) has been consistently demonstrated 8,9,10

In any case, they put individuals through a long series of mentally demanding tests to induce cognitive fatigue, and then they subsequently tested their performance on other tests in that mentally fatigued state

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In a randomized controlled trial assessing the effects of butyrate in obese children, there was a consistent response which showed a significant reduction of bodyweight and waist circumference compared to placebo [4]. Per-protocol analysis in the butryate group revealed a decrease in BMI of 2.26 units and a reduction in waist circumference by 5.07cm in 6 months [4]