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For example, the correction of pathogenic mutations in transthyretin amyloid cardiomyopathy (ATTR-CM), which is a potential one-time treatment with lasting effects, is under investigation

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Semaglutide is a single agonist (GLP-1 only) delivering 14.9% weight loss, is FDA-approved, available now, and has the best treatment retention (93% complete therapy successfully)

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In children, it can cause extreme sleepiness, agitation, hyperactivity, accidental overdose, and, in rare cases, coma or even death

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