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During osteoclast differentiation, the antioxidant arctigenin inhibits RANKL-induced MAPK activation and the activation of transcription factors such as NF-B and NFATc1 in a dose-dependent manner, thereby suppressing the differentiation and maturation of osteoclast precursors

Chronic inflammation, seen in conditions like rheumatoid arthritis and inflammatory bowel disease, is both a cause and consequence of sustained oxidative stress [13]

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