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For those affected by hemolytic anemia due to glutathione reductase deficiency, this testing offers a promising pathway to early diagnosis, personalized treatment, and the hope of novel therapies

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Thus, the loss of intracellular GSH in the presence of active generation of hydroperoxy-phospholipids could occur through several active mechanisms, including formation of GSH, export of GSSG, inadequate replenishment of GSH, or insufficient levels of GSSG reductase, each directly or indirectly dependent on the generation of hydroperoxy-phospholipids

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