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CTS binding to non-pumping Na,K-ATPase leads to Src-dependent transactivation of receptor tyrosine kinases (RTKs) such as the EGF receptor (EGFR), which converts CTS binding to activation of serine/threonine kinases, lipid kinases and lipases (Liu et al., 2004) or Src-independent pathway (Taurin et al., 2002)

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