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However, researchers and clinicians have observed its potential in a much broader population, especially in the context of: Visceral adiposity (deep belly fat) Growth hormone deficiency Cognitive aging Cardiometabolic risk reduction Its appeal lies in the ability to elevate IGF-1 (insulin-like growth factor-1) levels while preserving the bodys natural feedback mechanisms

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Nrf2 is involved in not only the regulation of GSH synthesis and reduction via upgrading some enzymes and proteins (SLC7A11, GCLM, GCLC, GR) but also the activation of GSH-dependent antioxidant enzymes (GPX, GST) [200, 201]