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Weight loss caused a temporary increase in IGF-1 concentrations (P = .03) and continued decrements in blood glucose levels (P = .0004 at 16 weeks)

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Mechanistically, miR-4488 targets both NFKB2 and RELB mRNAs, and these well-studied transcriptional modulators can dimerize and activate proinflammatory gene expression (Sun, 2011

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[DOI] [PubMed] [Google Scholar] 69.delCardayre SB, Stock KP, Newton GL, Fahey RC, Davies JE

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