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As Imperial College Londons Ivan Koychev noted: People exposed to GLP-1RAs over many years appear to have a lower risk of ever developing dementia, which suggests an influence on the earliest pathogenic processes rather than on established neurodegeneration. 2

However, each of the four products can be oxidized to 3-ketosteroids with a concomitant double bond isomerization to give progesterone, 17-hydroxyprogesterone, androstenedione, and testosterone, respectively (Figure 7), and the alternative route to the sex hormones is named the delta4-pathway