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Injectable peptides face particular hydrolysis risk once reconstituted because the aqueous environment provides abundant water molecules for the reaction

The anti-inflammatory signaling from BPC-157 addresses the inflammatory loop rather than just suppressing symptoms temporarily

Nevertheless, multiple clinical trials testing different cyclic dinucleotides [e.g., BMS-986301 (NCT03956680) or BI 1387446 (NCT04147234)] either alone or in combination with other cancer therapies are currently ongoing and will ultimately determine the future relevance of STING agonists in a clinical setting (www.clinicaltrials.gov)