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Although the primary endpoint 12-month smoking abstinence did not reach statistical significance, secondary outcomes were encouraging: dulaglutide was associated with reduced nicotine cravings, less post-cessation weight gain, and higher self-reported satisfaction with the quitting process []

[1] [3] Importantly, patients should seek urgent medical attention if they experience severe or persistent abdominal pain (especially if radiating to the back), repeated vomiting, inability to keep fluids down, signs of dehydration, or jaundice, as these may indicate serious conditions such as pancreatitis or gallbladder disease

More intensive skin brightening protocols may suggest dosages between 1,500 to 4,000 mg once or twice a week, but these higher doses require close medical guidance

The patient begins semaglutide at the standard starting dose and progresses through the initial titration steps