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Some people may experience side effects when taking adaptogenic herbs, such as: mood changes (irritability, agitation, depression) digestive Issues (e.g., stomach discomfort or diarrhea) drowsiness low blood pressure insomnia restlessness thyroid effects When to avoid If you are pregnant or breastfeeding or chestfeeding, it is recommended to avoid both rhodiola and ashwagandha

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In addition, there is evidence from preclinical studies that ES (POS in particular) affects mitochondria in the brain

We recorded the number of rats that maintained the initial position of firmly standing on the surface with posterior legs, with only limited movements around, as well as the number of those demonstrating no freezing behavior, quick exploration, and escaping from the elevated surface