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Semaglutide and liraglutide effects on central nervous system regulation GLP-1 and GLP-1RA are involved in the activation of various central nervous system (CNS) processes, including satiety, thermogenesis, blood pressure, neurogenesis, and inflammation reduction (15)

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Both oral and injectable semaglutide share a similar adverse effect profile, with gastrointestinal symptoms representing the most common tolerability concerns

To ensure proper injection technique, injecting the medication below the skin in the abdomen, thigh, or upper arm is essential