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Under hypoxic conditions, cells activate adaptive responses mediated by hypoxia-inducible factor-1 (HIF-1), which regulates genes involved in angiogenesis, cell survival, and glucose metabolism

Published in The New England Journal of Medicine in May 2025, this landmark study provides definitive evidence about how these two medications compare

In mitochondria, elevated levels of HIF enhance the upregulation of BNIP3L, resulting in increased mitophagy and decreased ROS production