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As a subtype of glial cells vital for retina structural support, cellular homeostasis maintenance, and blood-retina barrier preservation, its reactivation would decrease lglutamic acid uptake, which results in excitotoxicity, as well as sabotage the integrity of the blood-retina barrier, leading to ultimate retinal ganglia cell death and vision damage (Ren et al., 2020)

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Overall, with its low toxicity, multitarget effects, and potential to mitigate complications, Scrophularia radix represents a promising natural candidate in antidiabetic drug development