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A local reduction in cortical GABAergic synapses after a loss of endogenous brain-derived neurotrophic factor, as revealed by single-cell gene knock-out method
[96] found that sub-cutaneous administration of for 28 days liraglutide reduced pro-inflammatory cytokines in cartilage, whilst in a surgically induced (ACL transection) rat model of OA, subcutaneous Liraglutide reduced histological signs of cartilage degradation [97]
Hong MKH, Macintyre G, Wedge DC, Van Loo P, Patel K, Lunke S et al