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In Figure 4 It was observed that, compared to the normal architecture and regular pattern of hepatocytes with active vesicular nuclei in G1 (Normal control), the liver of G2 (MTX) showed central vein dilation and congestion (a in Figure 4B), Focal cell necrosis, hepatocyte nuclei of many cells are dark stained, and small apoptosis was also observed
The 52-week window isn't a deadline - it's a reminder that structural changes can accumulate quietly over months without producing obvious symptoms until something more dramatic, like a fracture, forces attention to them
A recent meta-analysis of 11 randomized controlled trials demonstrated a 13-percent relative risk reduction for all-cause death, along with significant risk reductions across multiple outcomes, including 16 percent for renal failure, 13 percent for congestive heart failure hospitalizations, 14 percent for major adverse cardiovascular events, 12 percent for stroke, 13 percent for non-fatal myocardial infarction and 14 percent for cardiovascular death
