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Recent studies have revealed that difficulty sleeping, one of the five symptoms scored for AMS, is more of an effect of hypoxia than closely related to other AMS symptoms, thereby removing the sleep component from the Lake Louise AMS score in 2018

Kalfa, Theodosia

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Alternatively, if cannabinoids are able to reduce the opening of hemichannels during a chronic inflammatory event, it may subsequently prevent excitotoxicity caused by excess glutamate and reduce the release of pro-inflammatory cytokines, thus maintaining neuronal and astrocyte viability (Froger et al., 2009