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Because sepsis rapidly changes the microenvironment and endothelial cells are one of the cell types that first sense the changes caused by sepsis and undergo extensive molecular adaptations (83), further research into the renal vascular EG could help physicians diagnose sepsis as early as possible, thereby providing the opportunity for early intervention

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68,70 Reaction of the bone marrow to endplate defects The physical breakage of the barrier between the disc and the vertebra with endplate fracture enhances fluid flow between the disc and the bone marrow

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