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Brown-Frandsen, S.P

63 The accumulated NAPQI depletes GSH in the endoplasmic reticulum to induce an oxidationreduction imbalance, which initiates the phosphorylation of eukaryotic initiation factor 2 (eIF2) to activate ATF6 and CHOP, eventually resulting in hepatocyte apoptosis (Figure 2)

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But access gaps persist, compounded drug risks remain, the long-term coverage picture beyond 2027 is uncertain, and anyone considering these medications still needs a physician's evaluation before starting