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It has garnered interest not only for its weight loss potential but also for its implications in managing type 2 diabetes

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As CCKR signaling can stimulate increases in intracellular calcium (Ca 2+ ) in rat islets and other cell types 21,29,30 and this could be the trigger for insulin secretion in a -cell, we measured cytosolic Ca 2+ in -cells of isolated mouse islets before and after the addition of 1 M CCK

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