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Tirzepatide went through rigorous clinical trials and became one of the most successful GLP-1 fat loss treatments in pharmaceutical history

Large randomized trials including the LEADER, SUSTAIN, STEP, and SURMOUNT studies monitored thousands of patients and found that moderate heart rate increases during GLP-1 therapy did not increase the risk of heart attacks or strokes

People are still buying a lot of snacks, crisps, chocolates and junk food

Risk factors for mood disturbance on GLP-1 may include history of eating disorders, rapid prior weight-loss attempts, high baseline stress, poor sleep quality, and genetic predispositions affecting serotonin or dopamine metabolism