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The concern stems from animal reproduction studies where these drugs affected normal fetal development pathways, though human pregnancy data remains limited because ethical guidelines prevent controlled trials in pregnant women

During surgery, this slower digestion can increase the risk of aspiration, where stomach contents enter the airway during anesthesia

Many studies revealed the existence of several miRNAs able to target NFE2L2 , resulting in NFE2L2 mRNA degradation and inhibition of NRF2 protein translation, such as miR-144, miR-28, miR-93, miR-153, miR-27a, miR142-5p, and miR-34

Promotional superlatives and headline marketing phrases appearing on the brand's website - including, without limitation, "Physician-Guided," "No Hidden Fees," "Doctor-led Plans & Coaching," and "Quality is our guarantee" - are explicitly identified in this article (including in the dedicated "About the Promotional Language" and "How to Read RxSpan MD's Marketing Language" sections) as brand-asserted marketing language and are not represented as independent third-party rankings, performance guarantees, or laboratory-verified claims by this publication